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Biochemical Society Transactions (2004) 32, (893–898) (Printed in Great Britain)

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Morton Medal Lecture

The ubiquitous phosphoinositides

P.J. Parker¹

Protein Phosphorylation Laboratory, London Research Institute CRUK, 44 Lincoln's Inn Fields, London EC2A 3PX, U.K.

Key words: phosphoinositide, protein domain, second messenger.

Abbreviations used: DAG, diacylglycerol; EEA1, early endosome antigen 1; ENTH, epsin N-terminal homology; PH, pleckstrin homology; PK(A/B/C), protein kinases A, B and C respectively; cPKC, classical PKC; PI, phosphoinositide; PI3K, PI 3-kinase; PI-PLC, PI-specific phospholipases C.

¹email Peter.Parker@cancer.org.uk

Abstract

There are now known to exist seven phosphoinositides all derived through various metabolic routes from the parent lipid phosphatidylinositol. With one additional metabolite, diacylglycerol, these represent a rich resource of bioactive lipids responsible for recruiting protein effectors and marking membrane compartments. The metabolic map of this pathway and the nature of the binding partner interactions are reviewed.

Received 26 August 2004

© 2004 Biochemical Society