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Volume 37, part 1
February 2009




Contents

Biochemical Society Focused Meetings

Independent Meeting




Biochemical Society Focused Meetings

Molecular Biology of Archaea
University of St Andrews, U.K., 19–21 August 2008
Edited by Stephen Bell (Oxford, U.K.) and Malcolm White (St Andrews, U.K.).
Methanococcus maripaludis: an archaeon with multiple functional MCM proteins?
Alison D. Walters and James P.J. Chong..........1–6
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How is the archaeal MCM helicase assembled at the origin? Possible mechanisms
Nozomi Sakakibara, Lori M. Kelman and Zvi Kelman..........7–11
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Molecular mechanisms of archaeal RNA polymerase
Dina Grohmann, Angela Hirtreiter and Finn Werner..........12–17
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Mutational studies of archaeal RNA polymerase and analysis of hybrid RNA polymerases
Michael Thomm, Christoph Reich, Sebastian Grünberg and Souad Naji..........18–22
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Distribution of CRISPR spacer matches in viruses and plasmids of crenarchaeal acidothermophiles and implications for their inhibitory mechanism
Shiraz Ali Shah, Niels R. Hansen and Roger A. Garrett..........23–28
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The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya
Arnaud Hecker, Marc Graille, Edwige Madec, Danièle Gadelle, Eric Le Cam, Herman van Tilbergh and Patrick Forterre..........29–35
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Reactions to UV damage in the model archaeon Sulfolobus solfataricus
Sabrina Fröls, Malcolm F. White and Christa Schleper..........36–41
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Molecular biology of the pRN1 plasmid from Sulfolobus islandicus
Georg Lipps..........42–45
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Chaperones and protein folding in the archaea
Andrew T. Large, Martin D. Goldberg and Peter A. Lund..........46–51
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Role of multiprotein bridging factor 1 in archaea: bridging the domains?
Bart de Koning, Fabian Blombach, Hao Wu, Stan J.J. Brouns and John van der Oost..........52–57
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SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation
Sonja-Verena Albers, Nils-Kåre Birkeland, Arnold J.M. Driessen, Susanne Gertig, Patrick Haferkamp, Hans-Peter Klenk, Theresa Kouril, Andrea Manica, Trong K. Pham, Peter Ruoff, Christa Schleper, Dietmar Schomburg, Kieran J. Sharkey, Bettina Siebers, Pawel Sierocinski, Ralf Steuer, John van der Oost, Hans V. Westerhoff, Patricia Wieloch, Phillip C. Wright and Melanie Zaparty..........58–64
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Recognition of deaminated bases by archaeal family-B DNA polymerases
Bernard A. Connolly..........65–68
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Reverse gyrase and genome stability in hyperthermophilic organisms
Giuseppe Perugino, Anna Valenti, Anna D'Amaro, Mosè Rossi and Maria Ciaramella..........69–73
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Molecular biology of Hel308 helicase in archaea
Isabel L. Woodman and Edward L. Bolt..........74–78
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Studies on the base excision repair (BER) complex in Pyrococcus furiosus
Shinichi Kiyonari, Saki Tahara, Maiko Uchimura, Tsuyoshi Shirai, Sonoko Ishino and Yoshizumi Ishino..........79–82
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Lessons from structural and biochemical studies on the archaeal exosome
Sophia Hartung and Karl-Peter Hopfner..........83–87
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Homologous recombination in Sulfolobus acidocaldarius: genetic assays and functional properties
Dennis W. Grogan..........88–91
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Genetic analyses in the hyperthermophilic archaeon Sulfolobus islandicus
Qunxin She, Changyi Zhang, Ling Deng, Nan Peng, Zhengjun Chen and Yun Xiang Liang..........92–96
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Expanding and understanding the genetic toolbox of the hyperthermophilic genus Sulfolobus
Michaela Wagner, Silvia Berkner, Malgorzata Ajon, Arnold J.M. Driessen, Georg Lipps and Sonja-Verena Albers..........97–101
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RecA family proteins in archaea: RadA and its cousins
Sam Haldenby, Malcolm F. White and Thorsten Allers..........102–107
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Selected oral communications
The haloarchaeal chromosome replication machinery
Stuart A. MacNeill..........108–113
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Genetics, biochemistry and structure of the archaeal virus STIV
Jennifer Fulton, Brian Bothner, Martin Lawrence, John E. Johnson, Trevor Douglas and Mark Young..........114–117
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Two unique membrane-bound AAA proteins from Sulfolobus solfataricus
Justyna Serek-Heuberger, Cédric F.V. Hobel, Stanislaw Dunin-Horkawicz, Beate Rockel, Jörg Martin and Andrei N. Lupas..........118–122
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Role of vapBC toxin–antitoxin loci in the thermal stress response of Sulfolobus solfataricus
Charlotte R. Cooper, Amanda J. Daugherty, Sabrina Tachdjian, Paul H. Blum and Robert M. Kelly..........123–126
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The interaction of Nanoarchaeum equitans with Ignicoccus hospitalis: proteins in the contact site between two cells
Tillmann Burghardt, Benjamin Junglas, Frank Siedler, Reinhard Wirth, Harald Huber and Reinhard Rachel..........127–132
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Small RNAs of the halophilic archaeon Haloferax volcanii
Jörg Soppa, Julia Straub, Mariam Brenneis, Angelika Jellen-Ritter, Ruth Heyer, Susan Fischer, Michaela Granzow, Björn Voss, Wolfgang R. Hess, Brian Tjaden and Anita Marchfelder..........133–136
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ESCRTs: from Cell Biology to Pathogenesis
Robinson College, Cambridge, U.K., 26–28 August 2008
Edited by Katherine Bowers (University College London, U.K.), Juan Martin-Serrano (King's College London, U.K.) and Paul Whitley (Bath, U.K.).
The role of ESCRT proteins in attenuation of cell signalling
Lina M. Rodahl, Susanne Stuffers, Viola H. Lobert and Harald Stenmark..........137–142
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Regulation of Vps4 ATPase activity by ESCRT-III
Brian A. Davies, Ishara F. Azmi and David J. Katzmann..........143–145
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ESCRT proteins, endosome organization and mitogenic receptor down-regulation
Philip Woodman..........146–150
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Evolution and assembly of ESCRTs
Sara Ghazi-Tabatabai, Takayuki Obita, Ajaybabu V. Pobbati, Olga Perisic, Rachel Y. Samson, Stephen D. Bell and Roger L. Williams..........151–155
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Structure and function of ESCRT-III
Suman Lata, Guy Schoehn, Julianna Solomons, Ricardo Pires, Heinrich G. Göttlinger and Winfried Weissenhorn..........156–160
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Piecing together the ESCRTs
James H. Hurley, Young Jun Im, Hyung Ho Lee, Xuefeng Ren, Thomas Wollert and Dong Yang..........161–166
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ESCRTs and human disease
Suraj Saksena and Scott D. Emr..........167–172
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Down-regulation of epidermal growth factor receptor signalling within multivesicular bodies
Emily R. Eden, Ian J. White and Clare E. Futter..........173–177
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ESCRT proteins and the regulation of endocytic delivery to lysosomes
J. Paul Luzio, Siân C. Piper, Katherine Bowers, Michael D.J. Parkinson, Paul J. Lehner and Nicholas A. Bright..........178–180
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The ESCRT pathway and HIV-1 budding
Yoshiko Usami, Sergei Popov, Elena Popova, Michio Inoue, Winfried Weissenhorn and Heinrich G. Göttlinger..........181–184
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HIV assembly and budding in macrophages
Mark Marsh, Kristina Theusner and Annegret Pelchen-Matthews..........185–189
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Selected oral communications
The mechanism of Ca2+-dependent recognition of Alix by ALG-2: insights from X-ray crystal structures
Hironori Suzuki, Masato Kawasaki, Tatsutoshi Inuzuka, Mayumi Okumura, Takeshi Kakiuchi, Hideki Shibata, Soichi Wakatsuki and Masatoshi Maki..........190–194
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The ESCRT machinery: new functions in viral and cellular biology
Jeremy G. Carlton and Juan Martin-Serrano..........195–199
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Alix and ALG-2 make a link between endosomes and neuronal death
Anne-Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, Sakina Torch, Fiona Hemming, Anne Petiot, Jean-Marc Verna, Sandrine Fraboulet and Rémy Sadoul..........200–203
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Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101
Hans-Martin Herz and Andreas Bergmann..........204–207
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The role of CHMP2B in frontotemporal dementia
Hazel Urwin, Shabnam Ghazi-Noori, John Collinge and Adrian Isaacs..........208–212
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mTOR Signalling, Nutrients and Disease
Medical Sciences Teaching Centre, University of Oxford, U.K., 15–16 September 2008
Edited by Richard Boyd (Oxford, U.K.), Deborah Goberdhan (Oxford, U.K.) and Richard Lamb (Cancer Research UK, London, U.K.).
mTOR: dissecting regulation and mechanism of action to understand human disease
Deborah C.I. Goberdhan and C.A. Richard Boyd..........213–216
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A complex interplay between Akt, TSC2 and the two mTOR complexes
Jingxiang Huang and Brendan D. Manning..........217–222
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Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
Joseph Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, Angela Papageorgiou, Noriko Oshiro and Ushio Kikkawa..........223–226
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mTORC1 signalling and mRNA translation
Christopher G. Proud..........227–231
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Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
Yu-Yun Chang, Gábor Juhász, Pankuri Goraksha-Hicks, Andrew M. Arsham, Daniel R. Mallin, Laura K. Muller and Thomas P. Neufeld..........232–236
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Amino acid transporters: éminences grises of nutrient signalling mechanisms?
Peter M. Taylor..........237–241
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Amino-acid-induced signalling via the SPS-sensing pathway in yeast
Per O. Ljungdahl..........242–247
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Amino acid sensing and mTOR regulation: inside or out?
Deborah C.I. Goberdhan, Margret H. ögmundsdóttir, Shubana Kazi, Bruno Reynolds, Shivanthy M. Visvalingam, Clive Wilson and C.A. Richard Boyd..........248–252
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Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression
Aimee L. Edinger..........253–258
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Therapeutic targeting of mTOR in tuberous sclerosis
Julian R. Sampson..........259–264
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PI3K inhibitors for cancer treatment: where do we stand?
Sauveur-Michel Maira, Frédéric Stauffer, Christian Schnell and Carlos García-Echeverría..........265–272
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Selected oral communications
TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress
Janni Petersen..........273–277
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A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size
Thomas Porstmann, Claudio R. Santos, Caroline Lewis, Beatrice Griffiths and Almut Schulze..........278–283
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Translational responses to growth factors and stress
Megan Cully and Julian Downward..........284–288
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Rag proteins regulate amino-acid-induced mTORC1 signalling
Yasemin Sancak and David M. Sabatini..........289–290
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Prolyl hydroxylases as regulators of cell metabolism
Houda Boulahbel, Raúl V. Durán and Eyal Gottlieb..........291–294
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Placental mTOR links maternal nutrient availability to fetal growth
Sara Roos, Theresa L. Powell and Thomas Jansson..........295–298
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Independent Meeting

2nd Neuroscience Ireland Conference
National University of Ireland, Galway, Co. Galway, Ireland, 28–29 August 2008
Edited by Karen Doyle (National University of Ireland, Galway, Ireland).
Considerations and recent advances in neuroscience
Adrienne M. Gorman and Karen M. Doyle..........299–302
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Neuroinflammatory changes increase the impact of stressors on neuronal function
Alessia Piazza and Marina A. Lynch..........303–307
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Mutant models for genes associated with schizophrenia
Lieve Desbonnet, John L. Waddington and Colm M.P. O'Tuathaigh..........308–312
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Is depression associated with dysfunction of the central reward system?
Chantal Martin-Soelch..........313–317
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When pain after surgery doesn't go away…
Siún Burke and George D. Shorten..........318–322
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Medium spiny neurons for transplantation in Huntington's disease
Claire M. Kelly, Stephen B. Dunnett and Anne E. Rosser..........323–328
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The effects of blood–brain barrier disruption on glial cell function in multiple sclerosis
Stephen McQuaid, Paula Cunnea, Jill McMahon and Una Fitzgerald..........329–331
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