Biochemical Society Transactions Most downloaded papers

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Most Read papers

Which papers published in the last 3 years are being downloaded the most?
The number of downloads in the 12 months to the end of January 2012 are shown below

1777	Inflammasome activation: from inflammatory disease to infection Aisling Dunne (2011) 39, 669-673 doi:10.1042/BST0390669 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1289	The involvement of microRNAs in TypeÂ 2 diabetes David Ferland-McCollough, Susan E Ozanne, Kenneth Siddle, Anne E Willis and Martin Bushell (2010) 38, 1565-1570 doi:10.1042/BST0381565 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1145	AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer D Grahame Hardie (2011) 39, 1-13 doi:10.1042/BST0390001 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1096	Inflammation: a role for NR4A orphan nuclear receptors? Jason P McMorrow and Evelyn P Murphy (2011) 39, 688-693 doi:10.1042/BST0390688 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1093	Exploring the LPS/TLR4 signal pathway with small molecules Francesco Peri, Matteo Piazza, Valentina Calabrese, Gaetana Damore and Roberto Cighetti (2010) 38, 1390-1395 doi:10.1042/BST0381390 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1085	The ground state of pluripotency Jason Wray, Tuzer Kalkan and Austin G Smith (2010) 38, 1027-1032 doi:10.1042/BST0381027 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1033	Regulation of the SREBP transcription factors by mTORC1 Caroline A Lewis, Beatrice Griffiths, Claudio R Santos, Mario Pende and Almut Schulze (2011) 39, 495-499 doi:10.1042/BST0390495 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1018	mTOR Signalling in Health and Disease Christopher G Proud (2011) 39, 431-436 doi:10.1042/BST0390431 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
996	On track with P-bodies Meeta Kulkarni, Sevim Ozgur and Georg Stoecklin (2010) 38, 242-251 doi:10.1042/BST0380242 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
988	Protein-protein interactions Mike P Williamson and Michael J Sutcliffe (2010) 38, 875-878 doi:10.1042/BST0380875 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
966	Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis Sanyukta Rana and Margot Zöller (2011) 39, 559-562 doi:10.1042/BST0390559 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
953	Cutting the nonsense: the degradation of PTC-containing mRNAs Pamela Nicholson and Oliver Mühlemann (2010) 38, 1615-1620 doi:10.1042/BST0381615 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
925	Interaction proteomics: characterization of protein complexes using tandem affinity purification-mass spectrometry Pamela Völkel, Perrine Le Faou and Pierre-Olivier Angrand (2010) 38, 883-887 doi:10.1042/BST0380883 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
921	A longer and healthier life with TOR down-regulation: genetics and drugs Ivana Bjedov and Linda Partridge (2011) 39, 460-465 doi:10.1042/BST0390460 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
838	Mitochondrial quality control by the ubiquitin-proteasome system Eric B Taylor and Jared Rutter (2011) 39, 1509-1513 doi:10.1042/BST0391509 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
833	Post-transcriptional and post-translational regulation of Bcl2 Shaun Willimott and Simon D Wagner (2010) 38, 1571-1575 doi:10.1042/BST0381571 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
827	Endosome-lysosome fusion J Paul Luzio, Sally R Gray and Nicholas A Bright (2010) 38, 1413-1416 doi:10.1042/BST0381413 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
791	The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions Eusebio Manchado, Manuel Eguren and Marcos Malumbres (2010) 38, 65-71 doi:10.1042/BST0380065 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
770	Cytoplasmic deadenylation: regulation of mRNA fate Katrin Wiederhold and Lori A Passmore (2010) 38, 1531-1536 doi:10.1042/BST0381531 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
757	Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis Yilin Huo, Valentina Iadevaia and Christopher G Proud (2011) 39, 446-450 doi:10.1042/BST0390446 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
689	The ‘anaphase problem‘: how to disable the mitotic checkpoint when sisters split María Dolores Vázquez-Novelle, Lesia Mirchenko, Frank Uhlmann and Mark Petronczki (2010) 38, 1660-1666 doi:10.1042/BST0381660 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
678	The tuberous sclerosis complex: balancing proliferation and survival Romana Tomasoni and Anna Mondino (2011) 39, 466-471 doi:10.1042/BST0390466 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
672	Diabetes as a risk factor for Alzheimer‘s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer‘s disease Christian Hölscher (2011) 39, 891-897 doi:10.1042/BST0390891 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
671	Regulation and biological function of the liver-specific miR-122 Andrew P Lewis and Catherine L Jopling (2010) 38, 1553-1557 doi:10.1042/BST0381553 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
662	A brief history of TOR Robbie Loewith (2011) 39, 437-442 doi:10.1042/BST0390437 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
653	Rab GTPases and microtubule motors Conor P Horgan and Mary W McCaffrey (2011) 39, 1202-1206 doi:10.1042/BST0391202 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
651	A new map to understand deubiquitination Elijah J Katz, Marta Isasa and Bernat Crosas (2010) 38, 21-28 doi:10.1042/BST0380021 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
639	SUMO and ubiquitin paths converge Amanda Denuc and Gemma Marfany (2010) 38, 34-39 doi:10.1042/BST0380034 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
629	Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase Vasundhara M Navadgi-Patil and Peter M Burgers (2011) 39, 600-605 doi:10.1042/BST0390600 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
605	Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation? Martina Schröder (2011) 39, 679-683 doi:10.1042/BST0390679 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
604	The therapeutic potential of deubiquitinating enzyme inhibitors Frédéric Colland (2010) 38, 137-143 doi:10.1042/BST0380137 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
591	The ribosome as a molecular machine: the mechanism of tRNA-mRNA movement in translocation Marina V Rodnina and Wolfgang Wintermeyer (2011) 39, 658-662 doi:10.1042/BST0390658 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
577	A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection Andrew P Halestrap (2010) 38, 841-860 doi:10.1042/BST0380841 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
571	Regulation of cyclin D1 gene expression Ini-Isabée Witzel, Li Fang Koh and Neil D Perkins (2010) 38, 217-222 doi:10.1042/BST0380217 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
563	Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling Melanie J Welham, Emmajayne Kingham, Yolanda Sanchez-Ripoll, Benjamin Kumpfmueller, Michael Storm and Heather Bone (2011) 39, 674-678 doi:10.1042/BST0390674 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
557	Assessing the contribution of inflammation in models of Alzheimer‘s disease Hannah Johnston, Herve Boutin and Stuart M Allan (2011) 39, 886-890 doi:10.1042/BST0390886 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
552	The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes Daniel Metcalf and Adrian M Isaacs (2010) 38, 1469-1473 doi:10.1042/BST0381469 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
550	Blocking the mTOR pathway: a drug discovery perspective Carlos Garcia-Echeverria (2011) 39, 451-455 doi:10.1042/BST0390451 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
541	Kinesin motors and primary cilia Kristen J Verhey, John Dishinger and Hooi Lynn Kee (2011) 39, 1120-1125 doi:10.1042/BST0391120 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
538	Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design John E Ladbury (2010) 38, 888-893 doi:10.1042/BST0380888 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
536	Mitophagy, mitochondrial dynamics and the general stress response in yeast Matthias Müller and Andreas S Reichert (2011) 39, 1514-1519 doi:10.1042/BST0391514 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
527	Ubiquitin and SUMO signalling in DNA repair Timothy M Thomson and Marta Guerra-Rebollo (2010) 38, 116-131 doi:10.1042/BST0380116 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
512	Hepatitis C virus entry and the tetraspanin CD81 Michelle J Farquhar, Helen J Harris and Jane A McKeating (2011) 39, 532-536 doi:10.1042/BST0390532 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
506	Benefits of mTOR kinase targeting in oncology: pre-clinical evidence with AZD8055 Gayle Marshall, Zoe Howard, Jonathan Dry, Sarah Fenton, Dan Heathcote, Neil Gray, Heather Keen, Armelle Logie, Sarah Holt, Paul Smith and Sylvie M Guichard (2011) 39, 456-459 doi:10.1042/BST0390456 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
504	Synaptic dysfunction in Parkinson‘s disease Vincenza Bagetta, Veronica Ghiglieri, Carmelo Sgobio, Paolo Calabresi and Barbara Picconi (2010) 38, 493-497 doi:10.1042/BST0380493 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
504	CRISPR-based immune systems of the Sulfolobales: complexity and diversity Roger A Garrett, Shiraz A Shah, Gisle Vestergaard, Ling Deng, Soley Gudbergsdottir, Chandra S Kenchappa, Susanne Erdmann and Qunxin She (2011) 39, 51-57 doi:10.1042/BST0390051 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
503	Alzheimer‘s disease genetics: lessons to improve disease modelling Rita J Guerreiro and John Hardy (2011) 39, 910-916 doi:10.1042/BST0390910 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
501	Pathways linking Abeta and tau pathologies Frank M LaFerla (2010) 38, 993-995 doi:10.1042/BST0380993 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
496	Pat1 proteins: a life in translation, translation repression and mRNA decay Aline Marnef and Nancy Standart (2010) 38, 1602-1607 doi:10.1042/BST0381602 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
495	Getting through anaphase: splitting the sisters and beyond Raquel A Oliveira and Kim Nasmyth (2010) 38, 1639-1644 doi:10.1042/BST0381639 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF