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Most downloaded papers

The papers listed below are the most frequently downloaded papers for the 12 months to the end of October 2008

Downloads Title / Authors
4573 Sir Frederick Gowland Hopkins Medal Lecture
Pleasant Surprises En Route from the Biochemistry of Collagen to Attempts at Gene Therapy
D. J. Prockop
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4287 VEGF signalling: integration and multi-tasking in endothelial cell biology
I. Zachary
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3922 Novartis Medal Lecture
Rho GTPases and the control of cell behaviour
A. Hall
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3762 Wellcome Trust Award Lecture
Integrin Structure
M. J. Humphries
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3622 Lipoprotein oxidation and atherosclerosis
I. S. Young and J. McEneny
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3615 Chemokine inhibition – why, when, where, which and how?
Z. Johnson, C.A. Power, C. Weiss, F. Rintelen, H. Ji, T. Ruckle, M. Camps, T.N.C. Wells, M.K. Schwarz, A.E.I. Proudfoot and C. Rommel
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3587 Peroxisomal fatty acid a- and b-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases
R. J. A. Wanders, P. Vreken, S. Ferdinandusse, G. A. Jansen, H. R. Waterham, C. W. T. van Roermund and E. G. Van Grunsven
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3334 Keilin Memorial Lecture
The molecular machinery of Keilin's respiratory chain
P.R. Rich
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3295 FOXO transcription factors: key regulators of cell fate
E.W.-F. Lam, R.E. Francis and M. Petkovic
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3243 Coping with stress: eIF2 kinases and translational control
R.C. Wek, H.-Y. Jiang and T.G. Anthony
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3206 Polyunsaturated fatty acid-specific elongation enzymes
T. Das, J. M. Thurmond, E. Bobik, A. E. Leonard, J. M. Parker-Barnes, Y.-S. Huang and P. Mukerji
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3174 Morton Lecture
Signalling through Class I PI3Ks in mammalian cells
P.T. Hawkins, K.E. Anderson, K. Davidson and L.R. Stephen
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3169 Jubilee Lecture
The Chemical and Biological Versatility of Riboflavin
V. Massey
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3132 Detecting, signalling and repairing DNA double-strand breaks
S. P. Jackson
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3035 Colworth Memorial Lecture
Cellular functions of the BRCA tumour-suppressor proteins
S.J. Boulton
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2749 PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases
R. Bordet, T. Ouk, O. Petrault, P. Gelé, S. Gautier, M. Laprais, D. Deplanque, P. Duriez, B. Staels, J.C. Fruchart and M. Bastide
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2659 Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain
J. Soulé, E. Messaoudi and C.R. Bramham
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2633 SUMO: getting it on
J. Anckar and L. Sistonen
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2546 Thudichum Medal Lecture
L-Glutamate as a Central Neurotransmitter: Looking Back
J. C. Watkins
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2539 HPV: from infection to cancer
M.A. Stanley, M.R. Pett and N. Coleman
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2505 The ubiquitin–proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand
P. van Kerkhof and G. J. Strous
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2488 Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
S. Patel, B. Doble and J.R. Woodgett
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2444 Colworth Medal Lecture
Discovery of PDK1, One of the Missing Links in Insulin Signal Transduction
D. R. Alessi
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2438 Signalling pathways and the regulation of SUMO modification
B. Guo, S.-H. Yang, J. Witty and A.D. Sharrocks
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2391 G-protein-coupled receptor signalling through protein networks
A.D. Strosberg and C. Nahmias
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2343 Signalling role of adipose tissue: adipokines and inflammation in obesity
P. Trayhurn and I.S. Wood
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2272 The role of the Wnt signalling pathway in colorectal tumorigenesis
J. Behrens
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2270 Role of adapters in Toll-like receptor signalling
S. Akira, M. Yamamoto and K. Takeda
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2264 Regulation of purine nucleotide biosynthesis: in yeast and beyond
R.J. Rolfes
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2245 Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
C. Alarcón de la Lastra1 and I. Villegas
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2244 Modulation of signal-transduction pathways by chemopreventive agents
M. M. Manson, K. A. Holloway, L. M. Howells, E. A. Hudson, S. M. Plummer, M. S. Squires and S. A. Prigent
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2180 Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes
X. Fang and G. Sweeney
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2176 Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses
S. Cabodi, L. Moro, E. Bergatto, E. Boeri Erba, P. Di Stefano, E. Turco, G. Tarone and P. Defilippi
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2165 Mechanisms of p53-dependent apoptosis
M. Schuler and D. R. Green
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2124 Interactions of the ergosterol biosynthetic pathway with other lipid pathways
M. Veen and C. Lang
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2109 Signalling molecules essential for neuronal survival and differentiation
K. Frebel and S. Wiese
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2070 Stress granules: sites of mRNA triage that regulate mRNA stability and translatability
N. Kedersha and P. Anderson
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1975 Physiological functions of protein kinase B/Akt
Z.-Z. Yang, O. Tschopp, A. Baudry, B. Dümmler, D. Hynx and B.A. Hemmings
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1969 Nod1 and Nod2 in innate immunity and human inflammatory disorders
L. Le Bourhis, S. Benko and S.E. Girardin
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1929 Structure and trafficking of NMDA and GABAA receptors
F.A. Stephenson
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1919 The twin-arginine transport system: moving folded proteins across membranes
F. Sargent
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1903 Role of reactive oxygen species in cell signalling pathways
J. T. Hancock, R. Desikan and S. J. Neill
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1900 Jubilee Lecture
Alternative mechanisms of initiating translation of mammalian mRNAs
R.J. Jackson
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1893 Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors
K.U. Birkenkamp and P.J. Coffer
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1883 Characterization of cancer stem cells in chronic myeloid leukaemia
H.G. Jørgensen and T.L. Holyoake
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1859 Myostatin: a modulator of skeletal-muscle stem cells
F.S. Walsh and A.J. Celeste
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1836 Lipase-catalysed production of biodiesel fuel from some Nigerian lauric oils
R. D. Abigor, P. O. Uadia, T. A. Foglia, M. J. Haas, K. C. Jones, E. Okpefa, J. U. Obibuzor and M. E. Bafor
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1827 LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport
M. Crestani, E. De Fabiani, D. Caruso, N. Mitro, F. Gilardi, A.B. Vigil Chacon, R. Patelli, C. Godio and G. Galli
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1784 Integrin regulation of cell signalling and motility
R.L. Juliano, P. Reddig, S. Alahari, M. Edin, A. Howe and A. Aplin
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1745 Small GTP-binding protein-coupled receptors
M. Bhattacharya, A.V. Babwah and S.S.G. Ferguson
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