Biochemical Society Transactions

678th Meeting of the Biochemical Society

Sulphotransferases acting on mucin-type oligosaccharides

I. Brockhausen


This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro, it is still difficult to determine exactly which enzymes are responsible for mucin sulphation in vivo. Sulphotransferases play a critical role in determining the chemical, physical and biological properties of mucins. Several of these enzymes have been shown to differ in expression and activity in cancer and inflammation.

  • biosynthesis of glycoproteins
  • inflammation
  • O-glycan
  • mucin
  • sulphotransferase


  • 678th Meeting of the Biochemical Society, held at Imperial College, London, 16–18 December 2002

  • Abbreviations used: CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; KS, keratan sulphate; PAPS, 3´-phosphoadenosine 5´-phosphosulphate; ST, sulphotransferase; TGN, trans-Golgi network; TNFα, tumour necrosis factor α.