The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.
- dehydroquinone inhibitor
- 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase)
- rational drug design
- shikimate pathway
Enzyme Mechanism – A Structural Perspective, a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003
Abbreviations used: EPSP synthase, 5-enolpyruvylshikimate-3-phosphate synthase; DHQase, dehydroquinase.
- © 2003 Biochemical Society