PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and rats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.
- bactericidal/permeability-increasing protein (BPI)
- gene expression
- gene structure
- host defence
- innate immunity
- lipopolysaccharide-binding protein (LBP)
- lung and nasal epithelium clone (PLUNC)
BPI-Like Proteins in Oral and Airway Epithelia a meeting held at Holiday Inn, Ventura, California, U.S.A., 7 February 2003
Abbreviations used: BASE, breast cancer and salivary expressed; BPI, bactericidal/permeability-increasing protein; EST, expressed sequence tag; LBP, lipopolysaccharide-binding protein; PLUNC, palate, lung and nasal epithelium clone; LPLUNC, long PLUNC; SPLUNC, short PLUNC; Psp, parotid salivary protein.
- © 2003 Biochemical Society