The eukaryotic cell-division cycle is regulated by three modules that control G1/S, G2/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.
- cell cycle
- mathematical model
Unravelling Nature's Networks a Biochemical Society Focused Meeting held at University of Sheffield, 21 July 2003
Abbreviations used: Cdk, cyclin-dependent kinase; APC, anaphase-promoting complex.
- © 2003 Biochemical Society