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Thermophiles 2003

Metagenomics, gene discovery and the ideal biocatalyst

D.A. Cowan, A. Arslanoglu, S.G. Burton, G.C. Baker, R.A. Cameron, J.J. Smith, Q. Meyer
Biochemical Society Transactions Apr 01, 2004, 32 (2) 298-302; DOI: 10.1042/bst0320298
D.A. Cowan
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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A. Arslanoglu
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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S.G. Burton
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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G.C. Baker
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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R.A. Cameron
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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J.J. Smith
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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Q. Meyer
Advanced Research Centre for Applied Microbiology, Department of Biotechnology, University of the Western Cape, Bellville 7535, Cape Town, South Africa
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Abstract

With the rapid development of powerful protein evolution and enzyme-screening technologies, there is a growing belief that optimum conditions for biotransformation processes can be established without the constraints of the properties of the biocatalyst. These technologies can then be applied to find the ‘ideal biocatalyst’ for the process. In identifying the ideal biocatalyst, the processes of gene discovery and enzyme evolution play major roles. However, in order to expand the pool genes for in vitro evolution, new technologies, which circumvent the limitations of microbial culturability, must be applied. These technologies, which currently include metagenomic library screening, gene-specific amplification methods and even full metagenomic sequencing, provide access to a volume of ‘sequence space’ that is not addressed by traditional screening.

  • biocatalyst
  • gene discovery
  • hyperthermophile
  • metagenome
  • sequence space
  • unculturable

Footnotes

  • Thermophiles 2003, a held at University of Exeter, 15–19 September 2003

  • © 2004 Biochemical Society
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April 2004

Volume: 32 Issue: 2

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Metagenomics, gene discovery and the ideal biocatalyst
D.A. Cowan, A. Arslanoglu, S.G. Burton, G.C. Baker, R.A. Cameron, J.J. Smith, Q. Meyer
Biochemical Society Transactions Apr 2004, 32 (2) 298-302; DOI: 10.1042/bst0320298
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Metagenomics, gene discovery and the ideal biocatalyst
D.A. Cowan, A. Arslanoglu, S.G. Burton, G.C. Baker, R.A. Cameron, J.J. Smith, Q. Meyer
Biochemical Society Transactions Apr 2004, 32 (2) 298-302; DOI: 10.1042/bst0320298

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Keywords

biocatalyst
gene discovery
hyperthermophile
metagenome
sequence space
unculturable

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