PI-3 Kinase in Signalling and Disease

Phosphoinositide 3-kinase: the protein kinase that time forgot

L.C. Foukas, P.R. Shepherd

Abstract

Class I phosphoinositide 3-kinases were originally characterized as lipid kinases, although more than 10 years ago they were also found to phosphorylate protein serine residues. However, while there is a vast amount of data on the function of this lipid kinase activity, relatively little is known about the function of the protein kinase activity. We discuss the evidence that suggests that the protein kinase activity of phosphoinositide 3-kinases mediates important signalling functions in cells.

  • phosphoinositide 3-kinase
  • phosphorylation
  • protein kinase
  • signalling

Footnotes

  • PI-3 Kinase in Signalling and Disease, a Biochemical Society Focused Meeting held at Novartis Horsham Research Centre, U.K., 11–12 November 2003

  • Abbreviations used: IRS, insulin receptor substrate; PI 3-kinase, phosphoinositide 3-kinase.