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BioScience2004

The anaphase-promoting complex (APC): the sum of its parts?

L.A. Passmore
Biochemical Society Transactions Nov 01, 2004, 32 (5) 724-727; DOI: 10.1042/BST0320724
L.A. Passmore
Section of Structural Biology, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, U.K.
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Abstract

The APC (anaphase-promoting complex) is a multisubunit E3 ubiquitin ligase that targets cell-cycle-related proteins for degradation by the 26 S proteasome. The APC contains at least 13 subunits and is regulated by the binding of co-activator proteins and by phosphorylation. It is not known why the APC contains 13 subunits when many other ubiquitin ligases are small single-subunit enzymes. In the present study, the structures and functions of individual APC subunits are discussed. By dissecting the roles of its parts, we hope to gain insight into the mechanism of the intact APC.

  • anaphase-promoting complex (APC)
  • cell cycle
  • cyclosome
  • E3 ligase
  • ubiquitin

Footnotes

  • Structure Related to Function: Molecules and Cells: A Focus Topic at BioScience2004, held at SECC Glasgow, U.K., 18–22 July 2004. Edited by D. Alessi (Dundee, U.K.), T. Cass (Imperial College London, U.K.), T. Corfield (Bristol, U.K.), M. Cousin (Edinburgh, U.K.), A. Entwistle (Ludwig Institute for Cancer Research, London, U.K.), I. Fearnley (Cambridge, U.K.), P. Haris (De Montfort, Leicester, U.K.), J. Mayer (Nottingham, U.K.) and M. Tuite (Canterbury, U.K.).

Abbreviations: APC, anaphase-promoting complex; RING, really interesting new gene; SCF, Skp1-Cdc53/Cul1-F-box protein; TPR, tetratricopeptide repeat

  • © 2004 The Biochemical Society
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November 2004

Volume: 32 Issue: 5

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The anaphase-promoting complex (APC): the sum of its parts?
L.A. Passmore
Biochemical Society Transactions Nov 2004, 32 (5) 724-727; DOI: 10.1042/BST0320724
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The anaphase-promoting complex (APC): the sum of its parts?
L.A. Passmore
Biochemical Society Transactions Nov 2004, 32 (5) 724-727; DOI: 10.1042/BST0320724

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  • Article
    • Abstract
    • Introduction
    • The mechanisms of E3s
    • The APC
    • Roles of cullin and RING (really interesting new gene) finger proteins
    • The Doc domain
    • Subunits containing TPRs (tetratricopeptide repeats)
    • Apc1
    • Subunits with unknown functions
    • The sum of its parts?
    • Acknowledgments
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Keywords

anaphase-promoting complex (APC)
cell cycle
cyclosome
E3 ligase
ubiquitin

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