The regulation of translation has emerged as a major determinant of gene expression and is critical for both normal cellular function and the development of disease. Numerous studies have highlighted the diverse, and sometimes related, mechanisms which underlie the regulation of global translation rates and the translational control of specific mRNAs. In the present paper, we discuss the emerging roles of the basal translation factor PABP [poly(A)-binding protein] in mRNA-specific translational control in metazoa which suggest that PABP function is more complex than first recognized.
- microRNA (miRNA)
- mRNA-specific translational control
- poly(A)-binding protein (PABP)
- Y-box 1 (YB-1)
Post-Transcriptional Control: mRNA Translation, Localization and Turnover: A Biochemical Society Focused Meeting held at University of Edinburgh, U.K., 8–10 June 2010. Organized and Edited by Matthew Brook (Edinburgh, U.K.), Mark Coldwell (Southampton, U.K.), Simon Morley (Sussex, U.K.) and Nicola Gray (Edinburgh, U.K.).
Abbreviations: ARS, autoregulatory site; CAF1, CCR4-associated factor 1; DAZ, deleted in azoospermia; DAZL, DAZ-like; DV, dengue virus; eIF, eukaryotic initiation factor; eRF3, eukaryotic release factor 3; IMP-1, insulin-like growth factor II mRNA-binding protein-1; miRNA, microRNA; msl-2, male-specific lethal 2; PABP, poly(A)-binding protein; ePABP, embryonic PABP; PAIP, PABP-interacting protein; RRM, RNA-recognition motif; SL, stem–loop; Sxl, sex-lethal; Unr, upstream of N-ras; UTR, untranslated region; YB-1, Y-box 1
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