From the pioneering work of Mabel and Lowell Hokin in the 1950s, the biology of this specific isomer of hexahydroxycyclohexane and its phosphorylated derivatives, in the form of inositol phosphates and phosphoinositides, has expanded to fill virtually every corner of cell biology, whole-organism physiology and development. In the present paper, I give a personal view of the role played by phosphoinositides in regulating the function of the endosomal network, and, in so doing, highlight some of the basic properties through which phosphoinositides regulate cell function.
- Bin/amphiphysin/Rvs domain (BAR domain)
- sorting nexin (SNX)
Abbreviations: Arp2/3, actin-related protein 2/3; BAR, Bin/amphiphysin/Rvs; CI-MPR, cation-independent mannose 6-phosphate receptor; DAG, 1-stearoyl 2-arachidonoyl diacylglycerol; EEA1, early endosomal antigen 1; EGFR, epidermal growth factor receptor; ERC, endocytic recycling compartment; ETC, endosome–trans-Golgi network carrier; FYVE, Fab1, YOTB, Vac1, EEA1 homology; ILV, intraluminal vesicle; PH, pleckstrin homology; PI3K, phosphoinositide 3-kinase; PX, phox homology; SNX, sorting nexin; TGN, trans-Golgi network; VPS, vacuolar protein sorting; WASP, Wiskott–Aldrich syndrome protein; WASH, WASP and Scar homologue
- © The Authors Journal compilation © 2011 Biochemical Society