Abstract
A major question in chromatin biology is to what extent the sequence of DNA directly determines the genetic and chromatin organization of a eukaryotic genome? We consider two aspects to this question: the DNA sequence-specified positioning of nucleosomes and the determination of NDRs (nucleosome-depleted regions) or barriers. We argue that, in budding yeast, while DNA sequence-specified nucleosome positioning may contribute to positions flanking the regions lacking nucleosomes, DNA thermodynamic stability is a major component determinant of the genetic organization of this organism.
- chromatin
- DNA structure
- histone
- nucleosome
- octamer
Footnotes
From Beads on a String to the Pearls of Regulation: the Structure and Dynamics of Chromatin: A joint Biochemical Society/Wellcome Trust Focused Meeting held at Wellcome Trust Genome Campus, Hinxton, Cambridge, U.K., 3–4 August 2011. Organized and Edited by Richard Bowater (University of East Anglia, U.K.), Ben Luisi (Cambridge, U.K.) and Ian Wood (Leeds, U.K.).
Abbreviations: HMGB, High-mobility group B; NDR, nucleosome-depleted region
- © The Authors Journal compilation © 2012 Biochemical Society
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April 2012
Volume: 40 Issue: 2
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