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Bioenergetics in Mitochondria, Bacteria and Chloroplast

Accessory subunits of mitochondrial complex I

Katarzyna Kmita, Volker Zickermann
Biochemical Society Transactions Sep 23, 2013, 41 (5) 1272-1279; DOI: 10.1042/BST20130091
Katarzyna Kmita
Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Cluster of Excellence Frankfurt ‘Macromolecular Complexes’, Goethe-University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt, Germany
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Volker Zickermann
Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Cluster of Excellence Frankfurt ‘Macromolecular Complexes’, Goethe-University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt, Germany
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Abstract

Mitochondrial complex I has a molecular mass of almost 1 MDa and comprises more than 40 polypeptides. Fourteen central subunits harbour the bioenergetic core functions. We are only beginning to understand the significance of the numerous accessory subunits. The present review addresses the role of accessory subunits for assembly, stability and regulation of complex I and for cellular functions not directly associated with redox-linked proton translocation.

  • accessory subunit
  • assembly
  • mitochondrion
  • NADH:ubiquinone oxidoreductase
  • respiratory complex I

Footnotes

  • Bioenergetics in Mitochondria, Bacteria and Chloroplasts: Third Joint German/UK Bioenergetics Conference, a Biochemical Society Focused Meeting held at Schloss Rauischholzhausen, Ebsdorfergrund, Germany, 10–13 April 2013. Organized and Edited by Fraser MacMillan (University of East Anglia, Norwich, U.K.) and Thomas Meier (Max Planck Institute of Biophysics, Frankfurt am Main, Germany).

Abbreviations: A, active; ACPM, mitochondrial acyl carrier protein; Bt, Bos taurus; D, deactive; GRIM-19, gene associated with retinoid/interferon-induced mortality 19; Hs, Homo sapiens; IFN, interferon; LDAO, N,N-dimethyldodecylamine-N-oxide; MTMD, multiple transmembrane domain; N-module, NADH oxidation module; PD-module, distal proton pump module; PKA, protein kinase A; PP-module, proximal proton pump module; Q-module, ubiquinone reduction module; RA, all-trans-retinoic acid; STAT3, signal transducer and activator of transcription 3; STMD, single transmembrane domain; Yl, Yarrowia lipolytica

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October 2013

Volume: 41 Issue: 5

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Accessory subunits of mitochondrial complex I
Katarzyna Kmita, Volker Zickermann
Biochemical Society Transactions Oct 2013, 41 (5) 1272-1279; DOI: 10.1042/BST20130091
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Accessory subunits of mitochondrial complex I
Katarzyna Kmita, Volker Zickermann
Biochemical Society Transactions Oct 2013, 41 (5) 1272-1279; DOI: 10.1042/BST20130091

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Keywords

accessory subunit
assembly
mitochondrion
NADH:ubiquinone oxidoreductase
respiratory complex I

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