Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications. Therefore such acetylation modifications might be coupled to the intracellular availability of acetyl-CoA. In the present article, we summarize recent evidence suggesting that the particular protein acetylation modifications enable the regulation of protein function in tune with acetyl-CoA availability and thus the metabolic state of the cell.
↵1 Benjamin Tu is a consultant and shareholder of Peloton Therapeutics, Inc.
Coenzyme A and Its Derivatives in Cellular Metabolism and Disease: A Biochemical Society Focused Meeting held at Charles Darwin House, London, U.K., 20–21 March 2014. Organized and Edited by Ivan Gout (University College London, U.K.), Suzanne Jackowski (St. Jude Children's Research Hospital, U.S.A.) and Ody Sibon (University of Groningen, The Netherlands).
Abbreviations: TCA, tricarboxylic acid; YMC, yeast metabolic cycle
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