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Behaviour Meets Biochemistry: Animals Making Sense of Molecules Making Scents

Pheromone-induced cell proliferation in the murine subventricular zone

Sachiko Koyama, Helena A. Soini, John Foley, Milos V. Novotny, Cary Lai
Biochemical Society Transactions Aug 11, 2014, 42 (4) 882-885; DOI: 10.1042/BST20140112
Sachiko Koyama
The Linda and Jack Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, U.S.A.
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  • For correspondence: sakoyama@indiana.edu
Helena A. Soini
Department of Chemistry and Institute for Pheromone Research, Indiana University, Bloomington, IN 47405, U.S.A.
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John Foley
Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, U.S.A.Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A.
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Milos V. Novotny
Department of Chemistry and Institute for Pheromone Research, Indiana University, Bloomington, IN 47405, U.S.A.
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Cary Lai
The Linda and Jack Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, U.S.A.
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Abstract

Enhancement of adult neurogenesis in female mice was previously demonstrated through exposure to soiled bedding from males, although the identity of relevant chemosignals has remained unknown. The farnesenes and SBT (2-sec-butyl-4,5-dihydrothiazole) are male murine pheromones that dominant males secrete at higher levels. Previous studies have shown that they induce oestrus in female mice. We have recently shown that these pheromones strongly increase cell proliferation in the SVZ (subventricular zone) of adult female mice. In addition, we found that a female murine pheromone, 2,5-dimethylpyrazine, facilitates similar changes in males. 2,5-dimethylpyrazine is a female pheromone that is secreted when females are housed in large groups and it was originally found to suppress oestrus in females. We found that it does not have suppressive effect on the cell proliferation in the SVZ of females. Similarly, male murine pheromones, SBT and the farnesenes, do not show a suppressive effect on the cell proliferation in the SVZ of males. Our results demonstrated that pheromonal communication between males and females has strong stimulatory effect on both the reproductive physiology and brain cell proliferation, but intrasex pheromonal exchanges do not reduce progenitor proliferation in these brain regions.

  • farnesene
  • neurogenesis
  • pheromone
  • 2-sec-butyl-4
  • 5-dihydrothiazole
  • subventricular zone

Footnotes

  • Behaviour Meets Biochemistry: Animals Making Sense of Molecules Making Scents: A joint Biochemical Society–Association for the Study of Animal Behaviour Focused Meeting held at Charles Darwin House, London, U.K., 18–20 February 2014. Organized and Edited by Rob Beynon and Jane Hurst (University of Liverpool, U.K.).

Abbreviations: DG, dentate gyrus; DHB, 3,4-dehydro-exo-brevicomin; GnRH, gonadotropin-releasing hormone; SBT, 2-sec-butyl-4,5-dihydrothiazole; Sox2, sex-determining region Y-box 2; SVZ, subventricular zone

  • © The Authors Journal compilation © 2014 Biochemical Society
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August 2014

Volume: 42 Issue: 4

Biochemical Society Transactions: 42 (4)
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Pheromone-induced cell proliferation in the murine subventricular zone
Sachiko Koyama, Helena A. Soini, John Foley, Milos V. Novotny, Cary Lai
Biochemical Society Transactions Aug 2014, 42 (4) 882-885; DOI: 10.1042/BST20140112
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Pheromone-induced cell proliferation in the murine subventricular zone
Sachiko Koyama, Helena A. Soini, John Foley, Milos V. Novotny, Cary Lai
Biochemical Society Transactions Aug 2014, 42 (4) 882-885; DOI: 10.1042/BST20140112

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  • Article
    • Abstract
    • Introduction
    • Primer effects in the brain of female mice
    • Age and the impact of exposure to pheromones
    • Direct/indirect contact and the impact of exposure to pheromones
    • Time length of exposure to pheromones and their impact
    • Concentration of pheromones and their effect on cell proliferation
    • Enhanced cell proliferation in the SVZ of males
    • Impact of exposure to pheromones of the same sex
    • Function of pheromonal enhancement of neurogenesis
    • Conclusion
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Keywords

farnesene
neurogenesis
pheromone
2-sec-butyl-4
5-dihydrothiazole
subventricular zone

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