The cytoplasmic dynein complex is the major minus-end-directed microtubule motor. Although its directionality is evolutionary well conserved, differences exist among cytoplasmic dyneins from different species in their stepping behaviour, maximum velocity and force production. Recent experiments also suggest differences in processivity regulation. In the present article, we give an overview of dynein's motile properties, with a special emphasis on processivity and its regulation. Furthermore, we summarize recent findings of different pathways for microtubule plus-end loading of dynein. The present review highlights how distinct functions in different cell types or organisms appear to require different mechanochemical dynein properties and localization pathways.
- BicaudalD (BicD)
- microtubule plus-end-tracking
The Dynamic Cell: held at Robinson College, Cambridge University, Cambridge, U.K., 4–7 September 2014.
Abbreviations: AAA, ATPase associated with various cellular activities; BicD2, BicaudalD2; CLIP-170, cytoplasmic linker protein 170; DHC, dynein heavy chain; DIC, dynein intermediate chain; DLIC, dynein light intermediate chain; EB1, end-binding protein 1; LC, light chain; LIS1, lissencephaly 1; mGFP, monomeric GFP; NudE, nuclear distribution E
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