TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.
- ion selectivity
- pH regulation
- mucolipin 1
Calcium Signalling: The Next Generation: Held at Charles Darwin House, London, U.K., 9–10 October 2014.
Abbreviations: MLIV, mucolipidosis type IV; MLSA1, mucolipin synthetic agonist 1; NAADP, nicotinic acid adenine dinucleotide phosphate; TPC, two-pore channel; TRP, transient receptor potential
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