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Signalling 2015: Cellular Functions of Phosphoinositides and Inositol Phosphates

Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways

Phillip T. Hawkins, Len R. Stephens
Biochemical Society Transactions Feb 09, 2016, 44 (1) 307-314; DOI: 10.1042/BST20150248
Phillip T. Hawkins
Signalling Programme, Babraham Institute, Cambridge CB22 3AT, U.K.
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  • For correspondence: phillip.hawkins@babraham.ac.uklen.stephens@babraham.ac.uk
Len R. Stephens
Signalling Programme, Babraham Institute, Cambridge CB22 3AT, U.K.
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  • For correspondence: phillip.hawkins@babraham.ac.uklen.stephens@babraham.ac.uk
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February 2016

Volume: 44 Issue: 1

Biochemical Society Transactions: 44 (1)
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Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways
Phillip T. Hawkins, Len R. Stephens
Biochemical Society Transactions Feb 2016, 44 (1) 307-314; DOI: 10.1042/BST20150248
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Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways
Phillip T. Hawkins, Len R. Stephens
Biochemical Society Transactions Feb 2016, 44 (1) 307-314; DOI: 10.1042/BST20150248

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  • Article
    • Abstract
    • Pathways for the formation of PI(3,4)P2
    • Direct effectors of PI(3,4)P2
    • Positive and negative roles for PI(3,4)P2 in Class I PI3K signalling
    • Roles for PI(3,4)P2 in different routes of endocytosis
    • Roles for PI(3,4)P2 in the formation of invadopodia, lamellipodia and membrane ruffles
    • Conclusions
    • Funding
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Keywords

Class I PI3K
Class II PI3K
CME
FEME
INPP4
PI(3,4)P2
PTEN
SHIP

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