Skip to main content

Main menu

  • Home
  • About the Journal
    • General Information
    • Scope
    • Editorial Board
    • Benefits of Publishing
    • Impact & Metrics
    • Advertising/Sponsorship
    • About the Biochemical Society
  • Current Issue
  • For Authors
    • Submit Your Paper
    • Instructions for Authors
    • Editorial Policy
    • Open Access Policy
    • Rights and Permissions
    • Biochemical Society Member Benefits
  • For Librarians
    • Subscriptions and Pricing
    • Check Your Usage
    • Promote to Your Users
    • Terms and Conditions
      • Biochemical Society Transactions- Terms and Conditions of Usage
    • Open Access Policy
    • FAQs for Librarians
    • Register for Free Trial
  • For Readers
    • Subscribe
    • Rights and Permissions
    • Recommend to Your Library
    • Biochemical Society Member Benefits
    • Journal Access for Biochemical Society Members
    • Request a Free Trial
  • Collections
  • Help
    • Technical Support
    • Contact Us
  • Other Publications
    • Biochemical Journal
    • Clinical Science
    • Bioscience Reports
    • Neuronal Signaling
    • Biochemical Society Transactions
    • Essays in Biochemistry
    • Emerging Topics in Life Sciences
    • Biochemical Society Symposia
    • Cell Signalling Biology
    • The Biochemist
    • Biochemical Society
    • Glossary of Biochemistry and Molecular Biology

User menu

  • Log-in
  • Subscribe
  • Contact Us

Search

  • Advanced search
  • Other Publications
    • Biochemical Journal
    • Clinical Science
    • Bioscience Reports
    • Neuronal Signaling
    • Biochemical Society Transactions
    • Essays in Biochemistry
    • Emerging Topics in Life Sciences
    • Biochemical Society Symposia
    • Cell Signalling Biology
    • The Biochemist
    • Biochemical Society
    • Glossary of Biochemistry and Molecular Biology

Log-in

Sign-up for alerts   
  • My Cart
Biochemical Society Transactions
Browse Archive
Advanced Search
  • Home
  • About the Journal
    • General Information
    • Scope
    • Editorial Board
    • Benefits of Publishing
    • Impact & Metrics
    • Advertising/Sponsorship
    • About the Biochemical Society
  • Current Issue
  • For Authors
    • Submit Your Paper
    • Instructions for Authors
    • Editorial Policy
    • Open Access Policy
    • Rights and Permissions
    • Biochemical Society Member Benefits
  • For Librarians
    • Subscriptions and Pricing
    • Check Your Usage
    • Promote to Your Users
    • Terms and Conditions
    • Open Access Policy
    • FAQs for Librarians
    • Register for Free Trial
  • For Readers
    • Subscribe
    • Rights and Permissions
    • Recommend to Your Library
    • Biochemical Society Member Benefits
    • Journal Access for Biochemical Society Members
    • Request a Free Trial
  • Collections
  • Help
    • Technical Support
    • Contact Us

Review Article

Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins

Julien Saint-Pol, Etienne Eschenbrenner, Emmanuel Dornier, Claude Boucheix, Stéphanie Charrin, Eric Rubinstein
Biochemical Society Transactions Jul 07, 2017, 45 (4) 937-944; DOI: 10.1042/BST20160296
Julien Saint-Pol
Inserm, U935, F-94807 Villejuif, FranceUniversité Paris-Sud, Institut André Lwoff, F-94807 Villejuif, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
Etienne Eschenbrenner
Inserm, U935, F-94807 Villejuif, FranceUniversité Paris-Sud, Institut André Lwoff, F-94807 Villejuif, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
Emmanuel Dornier
Université Paris-Sud, Institut André Lwoff, F-94807 Villejuif, FranceInserm, U1004, F-94807 Villejuif, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
Claude Boucheix
Inserm, U935, F-94807 Villejuif, FranceUniversité Paris-Sud, Institut André Lwoff, F-94807 Villejuif, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
Stéphanie Charrin
Inserm, U935, F-94807 Villejuif, FranceUniversité Paris-Sud, Institut André Lwoff, F-94807 Villejuif, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
Eric Rubinstein
Inserm, U935, F-94807 Villejuif, FranceUniversité Paris-Sud, Institut André Lwoff, F-94807 Villejuif, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
  • For correspondence: eric.rubinstein@inserm.fr
  • Article
  • Figures
  • Info & Metrics
  • PDF
Loading

Abstract

By interacting directly with partner proteins and with one another, tetraspanins organize a network of interactions referred to as the tetraspanin web. ADAM10 (A Disintegrin And Metalloprotease 10), an essential membrane-anchored metalloprotease that cleaves off the ectodomain of a large variety of cell surface proteins including cytokines, adhesion molecules, the precursor of the β-amyloid peptide APP or Notch, has emerged as a major component of the tetraspanin web. Recent studies have shown that ADAM10 associates directly with all members (Tspan5, Tspan10, Tspan14, Tspan15, Tspan17 and Tspan33) of a subgroup of tetraspanins having eight cysteines in the large extracellular domain and referred to as TspanC8. All TspanC8 regulate ADAM10 exit from the endoplasmic reticulum, but differentially regulate its subsequent trafficking and its function, and have notably a different impact on Notch signaling. TspanC8 orthologs in invertebrates also regulate ADAM10 trafficking and Notch signaling. It may be possible to target TspanC8 tetraspanins to modulate in a tissue- or substrate-restricted manner ADAM10 function in pathologies such as cardiovascular diseases, cancer or Alzheimer's disease.

  • ADAM10
  • metalloproteases
  • tetraspanins
  • Abbreviations

    ADAM10,
    A Disintegrin And Metalloprotease 10;
    APP,
    amyloid precursor peptide;
    Aβ,
    amyloid-beta;
    BMP,
    bone morphogenetic protein;
    CTF,
    carboxyterminal fragment;
    CXCL16,
    C-X-C motif chemokine ligand 16;
    EGF,
    epidermal growth factor;
    ER,
    endoplasmic reticulum;
    GWAS,
    genome-wide association studies;
    ICD,
    intracellular domain;
    KO,
    knockout;
    LEL,
    lLarge extracellular loop;
    SNP,
    single-nucleotide polymorphism;
    TNF,
    tumour necrosis factor
    • © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
    View Full Text

    Log in using your username and password

    Enter your Biochemical Society Transactions username.
    Enter the password that accompanies your username.
    Forgot your user name or password?

    Log in through your institution

    You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
    If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
    Previous ArticleNext Article
    Back to top

    August 2017

    Volume: 45 Issue: 4

    Biochemical Society Transactions: 45 (4)
    • Table of Contents
    • About the Cover
    • Index by author

    Actions

    Email

    Thank you for your interest in spreading the word about Biochemical Society Transactions.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins
    (Your Name) has forwarded a page to you from Biochemical Society Transactions
    (Your Name) thought you would like to see this page from the Biochemical Society Transactions web site.
    Share
    Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins
    Julien Saint-Pol, Etienne Eschenbrenner, Emmanuel Dornier, Claude Boucheix, Stéphanie Charrin, Eric Rubinstein
    Biochemical Society Transactions Aug 2017, 45 (4) 937-944; DOI: 10.1042/BST20160296
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Facebook logo Mendeley logo
    Citation Tools
    Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins
    Julien Saint-Pol, Etienne Eschenbrenner, Emmanuel Dornier, Claude Boucheix, Stéphanie Charrin, Eric Rubinstein
    Biochemical Society Transactions Aug 2017, 45 (4) 937-944; DOI: 10.1042/BST20160296

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Print
    Alerts

    Please log in to add an alert for this article.

    Request Permissions
    Save to my folders

    View Full PDF

     Open in Utopia Docs
    • Tweet Widget
    • Facebook Like

    Jump To

    • Article
      • Abstract
      • Introduction
      • A Disintegrin And Metalloprotease 10, a molecular scissor associated with the tetraspanin web
      • Direct association of ADAM10 with TspanC8 tetraspanins
      • TspanC8 tetraspanins differentially regulate ADAM10 trafficking and function
      • TspanC8 differentially regulate Notch signaling
      • Potential mechanisms whereby TspanC8 have differential effects on ADAM10 activity
      • The interaction of ADAM10 with non-TspanC8 tetraspanins
      • TspanC8 tetraspanin functions in invertebrates
      • TspanC8 tetraspanins in physiological processes and disease in mammals
      • Conclusions and perspectives
      • Funding
      • Competing Interests
      • References
    • Figures
    • Info & Metrics
    • PDF

    Keywords

    ADAM10
    metalloproteases
    tetraspanins

    Related Articles

    Cited By...

    • Portland Press Homepage
    • Publish With Us
    • Advertising
    • Technical Support
    • Clinical Science
    • Biochemical Journal
    • Biochemical Society Transactions
    • Bioscience Reports
    • Essays in Biochemistry
    • Emerging Topics in Life Sciences
    • Neuronal Signaling
    • Biochemical Society Symposia
    • Cell Signalling Biology

    Portland Press Limited
    Charles Darwin House
    12 Roger Street
    London WC1N 2JU
    Email: editorial@portlandpress.com

    The Biochemical Society