Mitochondria are highly dynamic organelles involved in various cellular processes such as energy production, regulation of calcium homeostasis, lipid trafficking, and apoptosis. To fulfill all these functions and preserve their morphology and dynamic behavior, mitochondria need to maintain a defined protein and lipid composition in both their membranes. The maintenance of mitochondrial membrane identity requires a selective and regulated transport of specific lipids from/to the endoplasmic reticulum (ER) and across the mitochondria outer and inner membranes. Since they are not integrated in the classical vesicular trafficking routes, mitochondria exchange lipids with the ER at sites of close apposition called membrane contact sites. Deregulation of such transport activities results in several pathologies including cancer and neurodegenerative disorders. However, we are just starting to understand the function of ER–mitochondria contact sites in lipid transport, what are the proteins involved and how they are regulated. In this review, we summarize recent insights into lipid transport pathways at the ER–mitochondria interface and discuss the implication of recently identified lipid transfer proteins in these processes.
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April 2018
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A 3D rendering of a Ubiquitin protein molecule. In this issue of Biochemical Society Transactions, Ovaa and Vertegaal discuss the role of ubiquitination and SUMO proteins in conjugation and deconjugation machineries; for details, see pages 423–436.
Review Article|
March 27 2018
Non-vesicular lipid trafficking at the endoplasmic reticulum–mitochondria interface
Francesca Giordano
1Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette cedex 91198, France
Correspondence: Francesca Giordano (francesca.giordano@i2bc.paris-saclay.fr)
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Publisher: Portland Press Ltd
Received:
December 17 2017
Revision Received:
February 20 2018
Accepted:
February 22 2018
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Biochem Soc Trans (2018) 46 (2): 437–452.
Article history
Received:
December 17 2017
Revision Received:
February 20 2018
Accepted:
February 22 2018
Citation
Francesca Giordano; Non-vesicular lipid trafficking at the endoplasmic reticulum–mitochondria interface. Biochem Soc Trans 17 April 2018; 46 (2): 437–452. doi: https://doi.org/10.1042/BST20160185
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