Table 1 Comparison of the H2O2 level, cyt c release, caspase-like activity and cell death rate en route to wild-type and mutant yeast cell AA-PCD

*, + and +++ indicate increase or decrease respectively of the measured parameter with respect to that measured in wild-type cells (++). −, undetectable; n.d., not determined.

Mutated gene(s)Mutation detailsH2O2 level*Cyt c releaseCaspase-like activity*AA-PCD death rate*References
None (wild-type)+++++++[18,20,24,25,40,41]
SOD1Overexpression+++n.dn.d.+++[18,20,24]
CTT1Overexpression+n.d.n.d.[18,20,24]
YCA1Knockout++++[25,40,41]
CYC1/CYC7Knockout++n.d++++[25,41]
YCA1/CYC1/CYC7Knockout++n.d.++++[25,41]