Table 1 Phenotype comparison of Ppp6c knockout and Ppp6r1 (SAPS1) knockout mice models [46 and unpublished data]
PP6c KOSAPS1 KO
Targeted genePppc6Ppp6r1 (SAPS1)
Chromosome locationChromosome 2Chromosome 7
Cre recombinaseLck-Cre, CD4-CreSox2-Cre
Splenic IL-4+CD4+ T cells (%)1UpUp
Splenic CD8+IL-4+ T cells (%)1UpNo difference
Splenic CD8+INFγ+ T cells (%)1UpNo difference
Phospho-p65/RelAUp2Up3

Following methods were used to measure the parameters: 1 Flow cytometry; 2immunoblot; 3RPPA.